Author:
Dilanyan S. V., ,Hovsepyan T. R.,Topuzyan V. O.,Minasyan N. S.,Stepanyan H. M.,Grigoryan A. S.,Aleksanyan E. R.,Harutyunyan A. A., , , , , , ,
Abstract
In order to find new biologically active compounds among 1,2,4-triazole derivatives, alkylation reactions of SH- and NH-tautomeric nucleophilic centers of the heterocycle with groups containing a polar substituent were carried out. The combination of hydrophobic groups in position 4 and polar groups in positions 3 and 5 of the triazole ring in the molecule will make it possible to trace the effect of increased polarity (hydrophilicity) of compounds on biological activity. It was shown that some derivatives of the synthesized 1,2,4-triazoles have moderate bacterial activity, some compounds have weak antimonoamineoxidase activity and are practically devoid of antiradical properties.
Publisher
National Academy of Sciences of the Republic of Armenia
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