Cравнительный анализ веществ пиридин-2-карбоксальдегид и наносеребро «Аргитос»

Abstract

The aim of the research was to study the possible therapeutic effect of "Argitos" in the form of a spray and liquid and Pyridine-2-carboxaldehyde (Tryptophan2PKA) in thermal burns. Studies have shown that the levels of blood parameters in the groups burn + "Argitos" (spray) and burn + "Argitos" (intraperitoneal injection -IP) differ from the control group (pure burn). With the IP administration of tryptophan- 2PKA, a tendency towards normalization and higher efficiency were observed in all blood parameters. Thanks to multi-regression analysis, it became possible to obtain equations according to which the coefficients for a clean burn and with the use of the above compounds are multidirectional which indicates a positive effect of the substances used. Summarizing the data of cytogenetic studies, we can conclude that "Argitos" in the form of a spray and liquid (PI) and Pyridine-2-carboxaldehyde (PI) have little effect on the cytogenetic status of experimental animals. Indicators with the introduction of Tryptophan2PKA are more preferable. Based on the survival rate, average life expectancy, cytogenetic and hematological parameters of rats, it can be concluded that the studied "Argitos" and Pyridine-2-carboxaldehyde in burns show little therapeutic effect. It is assumed that with the combined use of the above compounds with other substances, a result can be obtained that is much greater than the effect of the individual components (synergism).