Clinical Trial of Four Weeks of Combination Therapy with Low-dose Methimazole and a Cholesterol Absorption Inhibitor as the Initial Treatment for Childhood-onset Graves’ Disease

Author:

Takakuwa Satoshi1,Kina Yoko1

Affiliation:

1. Department of Pediatric Endocrinology and Metabolism, Okinawa Prefectural Nanbu Medical Center & Children’s Medical Center, Okinawa, Japan

Publisher

Japanese Society for Pediatric Endocrinology

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health

Reference17 articles.

1. 1. Sato H, Sasaki N, Harada S, Tanaka T, Akasu F, Asayama K, et al. Guidelines for the treatment of childhood-onset Graves’ disease with antithyroid drug in Japan, 2008. J Jpn Pediatr Soc 2008;112: 946-52.

2. 2. Rivkees SA, Mattison DR. Propylthiouracil (PTU) hepatoxicity in children and recommendations for discontinuation of use. Int J Pediatr Endocrinol 2009;2009:132041. doi: 10.1155/2009/132041.

3. 3. Rivkees SA, Szarfman A. Dissimilar hepatotoxicity profiles of propylthiouracil and methimazole in children. J Clin Endocrinol Metab 2010;95: 3260-7.

4. 4. Reinwein D, Benker G, Lazarus JH, Alexander WD. A prospective randomized trial of antithyroid drug dose in Graves’ disease therapy. European Multicenter Study Group on Antithyroid Drug Treatment. J Clin Endocrinol Metab 1993;76: 1516-21.

5. 5. Rivkees SA, Stepenson K, Dinauer K. Adverse events associated with methimazole therapy of Graves’ disease in children. Int J Pediatr Endocrinol 2009;2009:176970. doi: 10.1155/2009/176970.

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