Treatment situation of male hypogonadotropic hypogonadism in pediatrics and proposal of testosterone and gonadotropins replacement therapy protocols

Author:

Sato Naoko12,Hasegawa Tomonobu342,Hasegawa Yukihiro52,Arisaka Osamu64,Ozono Keiichi74,Amemiya Shin84,Kikuchi Toru94,Tanaka Hiroyuki42,Harada Shohei104,Miyata Ichiro114,Tanaka Toshiaki142

Affiliation:

1. Tanaka Growth Clinic, Tokyo, Japan

2. Study Group of Treatment for MHH

3. Department of Pediatrics, Keio University Hospital, Tokyo, Japan

4. Pharmaceutical Affairs Committee, the Japanese Society for Pediatric Endocrinology

5. Division of Endocrinology and Metabolism, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan

6. Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan

7. Department of Pediatrics, Osaka University, Osaka, Japan

8. Department of Pediatrics, Saitama Medical University, Saitama, Japan

9. Department of Pediatrics, Niigata University, Niigata, Japan

10. Division of Clinical Practice Policy, National Institute for Child Health and Development, Tokyo, Japan

11. Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan

Publisher

Japanese Society for Pediatric Endocrinology

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health

Reference24 articles.

1. 1. Han TS, Bouloux PM. What is the optimal therapy for young males with hypogonadotropic hypogonadism? Clin Endocrinol (Oxf) 2010;72: 731–7.

2. 2. Manual for the diagnosis and treatment of decreased gonadotropin secretion. Investigational research team for functional hypothalamic and pituitary disorders, research on measures for intractable diseases. Health and labor sciences research grant (http://rhhd.info/) (Only in Japanese).

3. 3. Oyama K, Nakagome Y, Kobayashi H, Satoh K, Uchida N, Sano T, et al. Examination of methods for inducing secondary sex characteristics for the treatment of male hypogonadotropic hypogonadism. Jap J Pediatr Soc 2008;112: 1667–73 (Only in Japanese).

4. 4. Rogol AD. New facets of androgen replacement therapy during childhood and adolescence. Expert Opin Pharmacother 2005;6: 1319–36.

5. 5. Nabhan Z, Eugster EA. Hormone replacement therapy in children with hypogonadotropic hypogonadism: where do we stand? Endocr Pract 2013;19: 968–71.

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