Synthesis, Characterization and Antimicrobial Activity of N-Pyridin-3-yl-benzenesulfonamide
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Published:2022-07-08
Issue:
Volume:
Page:163-173
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ISSN:2581-9003
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Container-title:Earthline Journal of Chemical Sciences
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language:en
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Short-container-title:EJCS
Author:
Ijuomah A.O.1, Ike D.C.1, Obi M.C.1
Affiliation:
1. Department of Chemistry, College of Physical Sciences, Joseph Sarwuan Tarka University Makurdi, Benue State, Nigeria
Abstract
This study describes a simple one-pot synthesis of N-pyridin-3-yl-benzenesulfonamide and its antimicrobial activity. The reaction of benzene sulfonyl chloride with 3-aminopyridine in the presence of aqueous Na2CO3 and HCl as a scavenger furnished the sulfonamide in 93.3% yield. The structure of the synthesized compound was established using the spectral data obtained from FTIR, 1HNMR and 13CNMR). All spectrometric spectrum bands and peaks obtained were sulfonamide-related. The antibacterial test carried out against Gram-positive bacterium (Staphylococcus aureus) and Gram-negative bacteria (Salmonella typhi and Eschericha coli) tested upon at concentrations 150, 100, 50 and 25 mg/ml revealed that the synthesized N-pyridin-3yl-benzenesulfonamide possesses great antimicrobial activity.
Publisher
Earthline Publishers
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