Author:
Sánchez-Viesca Francisco,Gómez Reina
Abstract
The recent interest for new applications of methylene blue as a promising drug for several important ailments prompted us to fill unknown aspects related to this compound. Since there is no mechanism on the Caro synthesis of methylene blue, we provide the electron flow, step by step, from the starting N,N-dimethylphenylenediamine to the dibenzothiazine derivative. It is a free radical generation system due to the oxidizing properties of ferric chloride. We pointed out the alternative reactions that take place with hydrogen sulphide, the reducer from which the thiazine ring is formed.
Reference20 articles.
1. Pioneering thinker ─ then and now: Methylene blue, BASF. Online access with the title. Last login, August 21, 2021. https://www.basf.com/global/en/media/magazine/archive/issue-4/pioneer-thinker-then-and-now-methlyene-blue.html
2. Methylene Blue ─ Existing Research and Chemical Potential, MITOLAB, November 23, 2017. https://mitolab.com/2017/11/methylene-blue-research/
3. F. Sánchez-Viesca and R. Gómez, On the chemistry of Sonnenschein test for strychnine, Am. J. Chem. 11(3) (2021), 49-51. https://doi.org/10.5923/j.chemistry.20211103.02
4. F. Sánchez-Viesca and R. Gómez, The chemistry of the Wellcome test for morphine, OAR J. Chem. & Pharm. 01(02) (2021), 001-004. https://doi.org/10.53022/oarjcp/2021.1.2.0025
5. F. Sánchez-Viesca and R. Gómez, The chemistry of Lindo and Fages colour tests, Earthline J. Chem. Sci. 5(1) (2021), 119-125. https://doi.org/10.34198/ejcs.5121.119125
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