Affiliation:
1. Department of Chemistry, Middle East Technical University, Üniversiteler, Eskişehir Yolu No: 1, 06800 Çankaya/Ankara, Turkey
Abstract
The present study considers some of dacarbazine tautomers having resulted from 1,3- and 1,5-proton migration. Density functional approach has been adopted at the level of B3LYP/6-311++G(d,p) in order to obtain various geometrical, physicochemical, spectral and quantum chemical properties of the tautomers of concern. Also local aromaticity of the imidazole ring in some of the tautomers having 6π-electrons has been obtained by calculating the nucleolus independent chemical shift values.
Reference39 articles.
1. Katzung, B.G. (1984). Basic and clinical pharmacology. Los Altros, California: Lange Medical Pub.
2. Ahlgren, J.D., & Macdonald, J.S. (1992). Gastrointestinal oncology. Philadelphia: J.B. Lippincott.
3. Rosenberg, S.A., Suit, H.D., & Baker, L.H. (1985). Sarcomas of soft tissue, in V.T. Devita, Jr., S. Hellman and S.A. Rosenberg, eds., Cancer: Principles and practice of oncology, 2nd ed., Philadelphia: J.B. Lippincott.
4. Wu, L-T., Averbuch, S.D., Ball, D.W., Bustros, A.D., Baylin, S.B., & McGuire, W.P. (1994). Treatment of advanced medullary thyroid carcinoma with a combination of cyclophosphamide, vincristine, and dacarbazine. Cancer, 73(2), 432-436. https://doi.org/10.1002/1097-0142(19940115)73:2%3C432::AID-CNCR2820730231%3E3.0.CO;2-K
5. Edmonson, J.H., Marks, R.S., Buckner J.C., & Mahoney, M.R. (2002). Contrast of response to dacarbazine, mitomycin, doxorubicin, and cisplatin (DMAP) Plus GM-CSF between patients with advanced malignant gastrointestinal stromal tumors and patients with other advanced leiomyosarcomas. Cancer Investigation, 20(5-6), 605-612. https://doi.org/10.1081/CNV-120002485