Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) new radiological features: a case report-Reference-Cited by-同舟云学术

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) new radiological features: a case report

Published:2022-10-19 Issue:3 Volume:13 Page:88-96
ISSN:2079-5343
Container-title:Diagnostic radiology and radiotherapy
language:
Short-container-title:Lučevaâ diagn. ter.

Author:

Khalilov V. S.¹^ORCID,Kislyakov A. N.²^ORCID,Medvedeva N. A.³^ORCID,Sadykova A. V.³^ORCID,Kopachev D. N.⁴^ORCID,Kholin А. A.⁵^ORCID

Affiliation:

1. Federal Research and Clinical Center for Children and Adolescents; Pirogov Russian National Research Medical University

2. Morozov Children Clinical Hospital

3. Federal Research and Clinical Center for Children and Adolescents

4. Scientiﬁc Center of Neurology

5. Pirogov Russian National Research Medical University

Abstract

A new form of morphologically and molecularly distinguishable epileptogenic neoplasia with characteristic microscopic findings and a distinct DNA methylation signature as well as frequent genetic anomalies, was revealed in 2017; the tumor was called polymorphous low-grade neuroepithelial tumor of the young (PLNTY). Several specific radiological patterns found in PLNTY when compared with the results of a pathomorphological study being useful in differential diagnosis with other epileptogenic tumors were mentioned in certain papers. Our paper is devoted to some particulars of the radiological picture in two children with pharmacoresistant epilepsy who underwent epileptic surgery with histological verification of PLNTY.

Publisher

Baltic Medical Education Center

Subject

General Medicine

Reference13 articles.

1. Slegers R.J., Blumcke I. Low-grade developmental and epilepsy associated brain tumors: a critical update 2020 // Acta Neuropathol. Commun. 2020. Vol. 8, No. 1. R. 27. R. 1–11 doi: 10.1186/s40478-020-00904-x. PMID: 32151273; PMCID: PMC7063704.

2. Huse J.T., Snuderl M., Jones D.T., Brathwaite C.D., Altman N. et al. Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): An Epileptogenic Neoplasm With Oligodendroglioma-Like Components, Aberrant CD34 Expression, and Genetic Alterations Involving the MAP Kinase Pathway // Acta Neuropathol. 2017. Vol. 133, No. 3. R. 417–429. doi: 10.1007/s00401-016-1639-9.

3. Benson J.C., Summerfield D., Carr C., Cogswell P., Messina S. et al. Polymorphous Low-Grade Neuroepithelial Tumor of the Young as a Partially Calcified IntraAxial Mass in an Adult // AJNR Am. J. Neuroradiol. 2020. Vol. 41, No. 4. R. 573–578. doi: 10.3174/ajnr.A6500.

4. Samura K., Morioka T., Yoshida F., Hashiguchi K., Miyagi Y. et al. Focal cortical dysplasia with calcification: a case report // Childs Nerv. Syst. 2008. Vol. 24. R. 619– 622. doi: 10.1007/s00381-007-0566-4.

5. Broggi G., Certo F., Altieri R., Caltabiano R., Gessi M. et al. A «polymorphous low-grade neuroepithelial tumor of the young (PLNTY)» diagnosed in an adult. Report of a case and review of the literature // Surg. Neurol. Int. 2021. Vol. 12. 470. R. 1–7. doi: 10.25259/SNI_500_2021.