Age and gender aspects of HIV-infected patients mortality

Abstract

Aim of study: to present the causes of mortality in HIV-infected patients, taking into account age and gender aspects.Materials and methods. The frequency, causes of mortality in the group of 284 HIV-infected patients are analyzed. Among them were 190 (66,9%) men, 94 (33,1%) women. The average age of patients was 45,3±4,2 years. The medical documentation of patients were retrospectively analyzed.Results. In the analyzed group of deceased HIV-infected patients, the overwhelming majority were young people under 40 years old (61.6%) compared with people who died between the ages of 41–50 years old — 73 (25,7%) and 51 years old and older 36 (12,7%) (p<0,05). In all age groups, the proportion of deceased men significantly (more than 2 times) exceeded the proportion of women. Among young males, co-infection with viruses of parenteral hepatitis, tuberculosis and alcohol abuse is more common. Over 70% of deceased patients did not receive ART or were on short courses of therapy (less than 1 year). The average life expectancy after HIV-infection diagnosis was 5,8±4,4 years and did not differ depending on the gender and age of the patients. AIDS-related causes of death accounted for 141 (49,6%) cases, nonAIDS-associated — 143 (50,4%). Among AIDSrelated causes, tuberculosis was the most frequent (59/20,8%). Among non AIDS-associated causes, death was associated with the decompensation of liver cirrhosis. A significant influence on the formation of AIDS-associated mortality of a complex of factors — co-infection with viruses of parenteral hepatitis, the presence of «advanced» stages of HIV infection, alcoholism and life expectancy with HIV infection, must be taken into account when monitoring HIV-infected patients.