Affiliation:
1. Scientific Centre of Family Health and Human Reproduction Problems
Abstract
Objective: to establish a correlation of the main neuroendocrine and metabolic parameters associated with infertility and to provide a prognostic assessment of reproductive disorders in HIV-infected women, stages 4.Materials and methods. Cross-sectional, cohort, clinical and sociological study of fertility of 83 women of reproductive age with HIV, stages 4.Results. The most significant indicators of lipid peroxidation and neuroendocrine regulation systems have been established in patients with HIV infection and reproductive disorders, which will make it possible to predict these disorders in the future. Decreased ovarian reserve, ovarian steroid function, increased pituitary prolactinergic function are associated with a deficiency of a number of antioxidants (retinol, tocopherol, superoxide dismutase) and the development of oxidative stress with a predominant accumulation of intermediate lipid peroxidation products in HIV-infected women with infertility.Conclusion. The pathogenetically substantiated principle of the correction of antioxidant status is the use of a-tocopherol and retinol preparations and the correction of hormonal levels in HIV-infected women with reproductive disorders.
Publisher
Baltic Medical Education Center
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health,Immunology
Reference15 articles.
1. Daar E.S., Daar J.F. Human immunodeficiency virus and fertility care: embarking on a path of knowledge and access // Fertil Steril. 2006. No. 85. P. 298–300. doi: 10.1016/j.fertnstert.2005.08.018.
2. Human immunodeficiency virus (HIV) and infertility treatment: a committee opinion // Fertil Steril. 2010. Vol. 104. No. 1. P. e1-e8. doi: 10.1016/j.fertnstert.2015.04.004.
3. Leshchenko O.Y., Genich E.V. Reproductive disorders and their pathogenetic mechanisms in women with HIV. HIV Infection and Immunosuppressive Disorders, 2019, No. 11 (4), рр. 20–29. doi: 10.22328/2077-9828-2019-114-20-29 (In Russ.).
4. Shugaeva S., Petrova A., Vaniarkina A., Rychkova L. Health problems in neonates with perinatal HIV exposure // Archives of Disease in Childhood. 2019. No. 104 (S3). Р. A143. doi: 10.1136/archdischild-2019-epa.329.
5. Petrova A., Vaniarkina A., Plotnikоva J., Rychkova L., Moskaleva E. Impact of combined antiretroviral prophylaxis on health outcomes in HIVexposed neonates // Archives of Disease in Childhood. 2019. No. 104 (S3). Р. A4. doi: 10.1136/archdischild-2019-epa.9.
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