Аnalysis of cases of progressive multifocal leukethephalopathy in patients with HIV infection: clinical, epidemiological, diagnostic and therapeutic aspects of the problem

Abstract

Purpose of research. Study of epidemiological, clinical, diagnostic and therapeutic features of progressive multifocal leukoencephalopathy in HIV-infected patients.Materials and methods. We analyzed 10 cases of deaths from PML of patients with HIV infection according to the reports of the Magnitogorsk AIDS Center for 2014–2016, and provided our own clinical observation of a patient with PML who was treated in 1 infectious Department of the South Ural State Medical University of the Ministry of Health of Russia in 2018 year.Results and discussion. In most cases of PML observed with CD4+ less than 50 cells and a viral load of more than 150 000 HIV RNA copies/ml, brain MRI is an informative method of in vivo diagnosis, WARTH slows the progression and improves the prognosis of patients.