Author:
Rassokhin V. V.,Bobrovitskaya T. M.,Belyakov N. A.
Abstract
Drug-induces and other iatrogenic lesions of kidney in HIV patients are inevitable upon ART and a therapy for the main opportunistic and concomitant conditions. Besides the direct effects of HIV, the side effects of drugs, such as acute renal lesions, crystal nephropathy, glomerulonephritis, acute and chronic renal failure, and functional renal impairments, are associated with poor ART efficacy and unfavorable prognosis and outcome. In the present paper, the morphological and clinical manifestations of ART-induced renal lesions are described. The main approaches to the early diagnostics of and screening for kidney lesions are suggested. The significance of the most prevalent functional and clinical renal disorders routinely encountered by physicians is evaluated.
Publisher
Baltic Medical Education Center
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health,Immunology
Reference140 articles.
1. Wyatt C.M., Klotman C.E. Antiretroviral therapy and the kidney: balancing benefit and risk in patients with HIV infection. Expert. Opin. Drug. Saf., 2006, No. 5, pp. 275–287.
2. Winston J.A., Bruggeman L.A., Ross M.D. et al. Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection. N. Engl. J. Med., 2001, No. 344, pp. 1979–1984.
3. National clinical guidelines «Chronic kidney disease in HIV-infected patients (causes, diagnosis, principles of management)». Eds. G.V.Volgina, M.M.Gadzhikulieva. Moscow, 2015 (In Russ.).
4. Belyakov N.A., Rassokhin V.V., Trofimova T.N., Stepanova E.V., Panteleev A.M., Leonova O.N., Buzunova S.A., Konovalova N.V., Milichkina A.M., Totolyan A.A. Comorbid and severe forms of HIV infection in Russia. HIV Infection and Immunosuppressive Disorders, 2016, Vol. 8, No. 3, pp. 9–24 (In Russ.).
5. Franceschini N., Napravnik S., Eron J.J. Jr., Szczech L.A., Finn W.F. Incidence and etiology of acute renal failure among ambulatory HIV infected patients. Kidney Int., 2005, Vol. 67 (4), pp. 1526–1531.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献