Wound dressings on the basis of seaweed polysaccharides, promising for the treatment of burn wounds

Abstract

INTRODUCTION. Severe burn injury or burn disease is one of the most dangerous injuries to life. Treatment of burns, as well as subsequent rehabilitation of the burn patients are a serious problem for both civil health care and military medicine. The key component of local treatment of burn wounds is the use of wound dressings. Among the wide variety of used wound dressings the most promising are hydrogel based on seaweed polysaccharides (PS). OBJECTIVE. Based on the analysis of data from domestic and foreign literature, to justify the use of seaweed polysaccharides (PS) as a basis or as therapeutic components of promising wound dressings for the treatment of wounds and burns. MATERIALS AND METHODS. The articles included in the databases and information systems are analyzed: the scientific electronic library Elibary.ru, RISC, Web of Science, Pubmed, Scopus, Elsevier and Google Scholar (as of February 2023) by keywords: marine medicine, burn wounds, seaweed polysaccharides, wound dressings, hydrogels RESULTS. The review presents information about modern biodegradable and biocompatible wounded dressings that have been used in clinical practice or are at the stage of experimental research and developed using seaweed PS (alginates and fucoidans of brown algae, carraginans of red algae, ulvanas of green algae) as a basis or as therapeutic components. A brief characteristic of the physicochemical properties and high biological activity of the PS, important both for macroorganism as a whole and for wounds healing is presented. DISCUSSION. The use of PS when constructing wound dressings is justified, and the results of their experimental and clinical trials for the treatment of wounds and burns are analyzed. Particular attention is paid to the ability of the PS to form hydrogel, since hydrogel dressings meet the main requirements for the ideal wound dressings for the treatment of wounds of various genesis, including burn wounds. CONCLUSION. Seaweed PS are widely used in modern technologies for creating wound dressings for the treatment of burn wounds.