Anti-inflammatory effect of hyperbaric oxygen in the treatment of peptic ulcer disease: review

Abstract

OBJECTIVE: Based on the analysis of literature data, highlight the mechanisms of anti-inflammatory action of hyperbaric oxygenation (HBO) in peptic ulcer of the stomach and duodenum (PUS and D).MATERIALS AND METHODS: The subject of study was scientific publications on the use of hyperbaric oxygenation (GBT) in treatment (PUS and D). The search was carried out on the international databases Elibrary, Pub Med, Scopus, Google Scholar from 1980–2022. A total of 38 literature sources were selected, of which at least 60% were published within the last five years. RESULTS: The effectiveness of the therapeutic effect of HBO (ulcer healing rate) in PUS and D depends on the location and size of the ulcer defect on the wall of the stomach or duodenum. At the moment, there is no conclusive data on the optimal number of HBO sessions required to achieve the maximum therapeutic effect in the treatment of PUS and D. DISCUSSION: The leading link in hyperoxic sanogenesis in this pathology is the anti-inflammatory effect of hyperbaric oxygen (HBO2), which is realized by: a) through stimulation of mucocyte formation; b) through regulation of HBO2 qualitative composition of mucocyte secretion; c) by stimulating the formation of bicarbonates by additional cells and increasing the sensitivity of these cells to their endogenous stimulant -solar acid (HCl); d) through the effect of HBO2 on gastrin formation (HCl stimulant), as well as on the diffusion of HCl from the gastric lumen into its capillary network. Together, this leads to a rapid cessation of pain syndrome, which creates conditions for the elimination of dyspeptic syndrome. This is realized through the restoration of the myoelectric activity of the stomach wall and duodenum, the regulation of the myogenic tone of their walls, as well as the elimination of the violation of gastric accommodation in the conditions of HBO. CONCLUSION: The anti-inflammatory effect of HBO2 in the treatment of PUS and D allows us to consider hyperbaric oxygenation as an integral part of the treatment of ulcerative lesion of the upper gastrointestinal tract.