Application of the 2014 NICE cholesterol guidelines in the English population: a cross-sectional analysis

Author:

Ueda Peter,Lung Thomas Wai-Chun,Clarke Philip,Danaei Goodarz

Abstract

BackgroundThe 2014 guidelines on cardiovascular risk assessment and lipid modification from the National Institute for Health and Care Excellence (NICE) recommend statin therapy for adults with prevalent cardiovascular disease (CVD), and for adults with a 10-year CVD risk of ≥10%, estimated using the QRISK2 algorithm.AimTo determine risk factor levels required to exceed the risk threshold for statin therapy, and to estimate the number of adults in England who would require statin therapy under the guidelines.Design and settingCross-sectional study using a sample representative of the English population aged 30–84 years.MethodTo estimate 10-year CVD risk different combinations of risk factor levels were entered into the QRISK2 algorithm. The NICE guidelines were applied to the sample using data from the Health Survey for England 2011.ResultsEven with optimal risk factor levels, males of different ethnicities would exceed the 10% risk threshold between the ages of 60 and 70 years, and females would exceed the threshold between 65 and 75 years. Under the NICE guidelines, 11.8 million males and females (37% of the adults aged 30–84 years) would require statin therapy, most of them (9.8 million) for primary prevention. When analysed by age, 95% of males and 66% of females without CVD in ages 60–74 years, including all males and females in ages 75–84 years, would require statin therapy.ConclusionUnder the 2014 NICE guidelines, 11.8 million (37%) adults in England aged 30–84 years, including almost all males >60 years and all females >75 years, require statin therapy.

Publisher

Royal College of General Practitioners

Subject

Family Practice

Reference26 articles.

1. National Institute for Health and Care Excellence. (2014) Cardiovascular disease: risk assessment and reduction, including lipid modification. CG181. (NICE, London) https://www.nice.org.uk/guidance/cg181 (accessed 6 Jul 2017).

2. National Institute for Health and Clinical Excellence. (2008) Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. CG67. (NICE, London).

3. Doctors no longer have to use Framingham equation to assessheart disease risk, NICE says

4. Mass treatment with statins

5. Statins for primary prevention of cardiovascular disease

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