In-Vitro And In-Vivo Assessment of Antigen-Encapsulated Dextran Nanoparticles

Abstract

Dextran nanoparticles have become increasingly popular for drug delivery purposes. They are known for their improved stability, low toxicity, simple and gentle preparation process, and versatility in terms of administration methods. The small size of the particles is not only suitable for parenteral administration, but also appropriate for mucosal routes of administration like oral, nasal, and ocular mucosa. These routes are typically less intrusive. The dextran absorption enhancing effect also helps in making the application of mucosal delivery easier. In addition, dextran nanoparticles have shown great potential as an effective adjuvant in the field of vaccines. Therefore, the main objectives of this review are to offer a thorough summary of the different methods used to prepare dextran nanoparticles, explore the wide range of applications for these nanoparticles, and clarify how they are able to enter cells.