Author:
A. Sharma,S. Mukati,A. Koshta,S. Malviya,A. Kharia
Abstract
The purpose of this investigation was to develop a formulation of amoxicillin and potassium clavulanate in chocolate form. Amoxicillin is an antibiotic belonging to the beta-lactam family. By binding to penicillin-binding proteins, beta-lactams stimulate autolytic enzymes in the bacterial cell wall, which in turn inhibits transpeptidation (the cross-linking stage in cell wall production). The streptomyces-derived, semi-synthetic beta-lactamase inhibitor potassium clavulanate. Multiple bacterial infections may be treated well with the antibiotic combination of amoxicillin and potassium clavulanate acid. It prevents germs from multiplying. Chocolate refers to a family of sweets made by combining cocoa (cacao), cocoa butter, and sugar in various proportions to form a solid. For improved patient compliance, the medicated chocolate formulation is often utilized for pediatric administration. The traditional chocolate formulation, which includes cocoa powder, moisture content, and blooming tests, is inferior to the one that incorporates carob powder, which lowers gastrointestinal troubles. The whole medication from the F4 formulation is released within 60 minutes, leading to a wide range of GIT disorders such heartburn and acid reflux. The formulation is stable throughout chocolate formulation manufacturing, with no drug excipient interactions and no drug degradation detected. The dimensions of the finished product are 28.5mm in length, 18mm in width, and 14mm in height. Batch F4 is the finest of all batches.
Publisher
Lloyd Institute of Management and Technology