The Interrelationship Among Non-Alcoholic Fatty Liver Disease, Colonic Diverticulosis and Metabolic Syndrome

Abstract

Non-alcoholic fatty liver disease and colonic diverticulosis are widespread, obesity-related diseases. It hasrecently become clear that non-alcoholic fatty liver disease is a systemic disease and may play a key rolein metabolic syndrome; therefore, the term metabolic-dysfunction-associated fatty liver disease has beenintroduced in the literature. Excess visceral adipose tissue is an important predictor of complications in bothnon-alcoholic fatty liver disease and colonic diverticulosis. Current evidence suggests that intestinal dysbiosismay be involved in the development of both non-alcoholic fatty liver disease and colonic diverticulosis, andthat metabolic syndrome is a consequence rather than a cause of this complex relationship. In this review, ouraim was to assess the current knowledge of the complex interplay between metabolic syndrome, non-alcoholicfatty liver disease, and colonic diverticulosis.