Author:
Taru Vlad,Indre Madalin Gabriela,Ignat Mina Dana,Forgione Antonnela,Racs Tamas,Olar Bianca Alina,Farcau Oana,Chereches Razvan,Stefanescu Horia,Procopet Bogdan
Abstract
Background and Aims: Health-related quality of life is an essential part of managing chronically ill patients, including patients with chronic liver disease. Various methods are used to try to assess the quality of life ranging from generic to disease-specific questionnaires. Some of the results may reveal a novel connection to the disease‘s evolution, which is observed directly by the patient. This study aimed to validate and assess the chronic liver disease questionnaire (CLDQ-RO) performance in the Romanian population.
Methods: A two-phase study was designed. The first phase consisted of linguistic validation of CLDQ-RO (translation and piloting), while in the second phase, the questionnaire was applied to patients with various chronic liver diseases. Statistical validation (reliability, structural, and construct validity) was performed using SPSS v20.0, and statistical significance was considered p<0.05.
Results: The CLDQ-RO was applied to 231 patients with chronic liver disease (14.3% with chronic hepatitis, 35.5% with compensated cirrhosis, and 50.2% with decompensated cirrhosis). The questionnaire showed excellent overall reliability (Cronbach‘s alpha=0.93) and good structural and construct validity, with most of the items in CLDQ-RO fitting in the domains of the original version of the questionnaire. There was a significant decrease in the overall score of the CLDQ-RO with the progression of disease (p<0.001), indicating a substantial impact of the decompensation event on health-related quality of life. Regarding the type of decompensation, ascites accurately predicted a lower quality of life (p=0.004).
Conclusions: The CLDQ-RO is a valid and disease-specific method for assessing patients‘ health-related quality of life with liver disease. Among the decompensation events, it seems that ascites seriously impacts the quality of life.
Publisher
Romanian Society of Gastroenterology and Hepatology
Cited by
4 articles.
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