Thrombospondin 1 and Nuclear Factor Kappa B Signaling Pathways in Non-alcoholic Fatty Liver Disease
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Published:2022-09-15
Issue:3
Volume:31
Page:309-316
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ISSN:1842-1121
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Container-title:Journal of Gastrointestinal and Liver Diseases
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language:
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Short-container-title:JGLD
Author:
Ekinci Iskender,Dumur Seyma,Uzun Hafize,Anataca Gulden,Yalcinkaya Isa,Buyukkaba Mitat,Cinar Ahmet,Ozkan Hanise,Utku Irem Kirac,Akarsu Murat,Tabak Omur
Abstract
Aim: We aimed to evaluate the circulating thrombospondin-1 (TSP-1) and nuclear factor kappa B (NF-κB) in nonalcoholic fatty liver disease (NAFLD) in order to integrate these signaling pathways in the inflammatory and fibrogenic processes of this liver disorder.
Methods: Ninety-five NAFLD patients were recruited in the study. The study also included 83 age-sex matched healthy controls.
Results: The number of patients with metabolic syndrome (MetS) criteria was 57 (60%). TSP-1 level was found to be statistically significantly lower in the NAFLD group compared to the control group (p=0.037). However, NF-κB level was found to be significantly higher in the NAFLD group compared to the control group (p=0.004). There was a significant negative correlation between plasma TSP-1 levels with glucose (r=-0.235, p=0.022), alanine aminotransferase (r=-0.261, p=0.011) and aspartate transaminase (r=-0.328, p=0.001) levels. In addition, a significant negative correlation was found between plasma TSP-1 and NF-κB levels (r=-0.729, p<0.001).
Conclusions: Our results suggest a close relationship between increased NF-κB and reduced TSP-1 in NAFLD. TSP-1 and NF-κB signaling pathways might have a role in the inflammatory and fibrogenic processes. Furthermore, they may be used as a noninvasive marker and could assist as a therapeutic target for NAFLD.
Publisher
Romanian Society of Gastroenterology and Hepatology
Cited by
1 articles.
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