Biological Activity of Levan Produced from Rhizospheric Soil Bacterium Brachybacterium phenoliresistens KX139300
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Published:2018-09-13
Issue:3
Volume:15
Page:238-243
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ISSN:2411-7986
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Container-title:Baghdad Science Journal
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language:
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Short-container-title:Baghdad Sci.J
Author:
Journal Baghdad Science
Abstract
Levan is an exopolysaccharide produced by various microorganisms and has a variety of applications. In this research, the aim was to demonstrate the biological activity of levan which produced from B. phenoliresistens KX139300. These were done via study the antioxidant, anti-inflammatory, anticancer and antileishmanial activities in vitro. The antioxidant levan was shown 80.9% activity at 1250 µg/mL concentration. The efficient anti-inflammatory activity of 88% protein inhibition was noticed with levan concentration at 35 µg/mL. The cytotoxic activity of levan at 2500 µg/mL concentration showed a maximum cytotoxic effect on L20B cell line and promastigotes of Leishmani tropica. Levan has dose-dependent anticancer and antileishmanial activities. An addition to the antioxidant, anti-inflammatory and anticancer potential activities of levan, it can be concluded that levan produced from B. phenoliresistens can efficiently be applied as an antileishmanial agent.
Publisher
College of Science for Women
Subject
General Physics and Astronomy,Agricultural and Biological Sciences (miscellaneous),General Biochemistry, Genetics and Molecular Biology,General Mathematics,General Chemistry,General Computer Science
Cited by
3 articles.
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