Acil Servise Başvuran ve Mekanik Trombektomi Uygulanan Akut İnme Hastalarında Serum Allopregnanolon Düzeylerinin Değerlendirilmesi

Abstract

Objectives: Ischemic stroke is a disease that occurs as a result of impaired perfusion of the brain and is the second most common cause of death after cardiovascular diseases. Biochemical marker studies for early diagnosis of stroke patients and predicting the prognosis of patients have been the focus of the attention of researchers. Our primary aim in this study was to examine the change in serum Allopregnanolone levels in patients with ischemic stroke who underwent mechanical thrombectomy. Methods: Patients diagnosed with ischemic stroke and underwent mechanical thrombectomy in Samsun Training and Research Hospital Emergency Service between December 2020 and February 2021 were included in the study. Serum Allopregnanolone levels from blood samples were measured by Enzyme-Linked Immuno Sorbent Assay (ELISA) method. Results: Twenty-two stroke patients who underwent mechanical thrombectomy and 20 healthy volunteers were included in the study. The mean serum Allopregnanolone value at 0h was 56,439 (31.71-253.07), and the median serum Allopregnanolone value of the healthy control group was 51.219 (23.43-87.98), and no statistically significant difference was found (p=0.078). No significant difference existed between the patient group's 0th-hour, 12th-hour, and 5th-day Allopregnanolone levels (p=0.554). There was no significant relationship between the serum Allopregnanolone levels at the 0th hour, 12th hour, and 5th day of the patient group and the 3rd-month mRS scores (p=0.713, p=0.616, p=0.867, respectively). Conclusion: Serum Allopregnanolone levels do not help diagnose, treat, and prognosis of patients with acute ischemic stroke who underwent mechanical thrombectomy. A clinical study with more patients should be updated with our findings.