The clinical characteristics and related factors of centrally mediated abdominal pain syndrome

Abstract

Abstract Objective: To explore the clinical characteristics and related factors of centrally mediated abdominal pain syndrome (CAPS). Methods: Our study included 73 CAPS patients and 132 age- and gender-matched healthy controls. The general information of the participants was collected and the questionnaires were completed including 7-item Generalized Anxiety Disorder scale, the 9-item Patient Health Questionnaire, the Hamilton Anxiety Scale, the Hamilton Depression Scale Pittsburgh sleep quality index, visual analogue scale and Short Form 36. Univariate and forward stepwise regression analysis was performed to explore the influencing factors of centrally mediated abdominal pain syndrome. Results: Non-exercise, mild to moderate depression, married status and drinking coffee (AOR=4.53 CI (1.602∼12.809); AOR=7.931 CI(3.236∼19.438); AOR=3.656 CI(1.317∼10.418); AOR=0.199 CI(0.051∼0.775) ) were found to be related with centrally mediated abdominal syndrome. The Hamilton Anxiety Scale score (7-13) was significantly related to moderate to severe abdominal pain (AOR=7.043 CI(1.319∼37.593)) . Higher Hamilton Depression Scale score was related to lower mental component scale score (β=-0.726, p<0.01 ) and physical component scale score (β=-0.706, p<0.01). Conclusion: Depression, married status and non-exercise were the independent risk factors of centrally mediated abdominal pain syndrome. Conversely, coffee intake was an independent protective factor of centrally mediated abdominal pain syndrome. Anxiety was related to the severity of abdominal pain, while depression was related to low health-related quality of life.