Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori–Infected Patients Undergoing Upper Endoscopy-Reference-Cited by-同舟云学术

Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori–Infected Patients Undergoing Upper Endoscopy

Published:2024-05-14 Issue:6 Volume:15 Page:e1
ISSN:2155-384X
Container-title:Clinical and Translational Gastroenterology
language:en
Short-container-title:Clin Transl Gastroenterol

Author:

Epplein Meira¹²,McCall Shannon J.³,Wang Frances⁴,Alagesan Priya⁵,Brown HannahSofia⁶,Wawrzynski Joseph⁷,Labriola Caroline⁵,Zuzul Rachel⁵,Cook Christian⁸,Dillon Melanie⁹,Hyslop Terry¹⁴¹⁰,Patierno Steven R.¹⁶,Salama Nina R.⁹,Garman Katherine S.¹⁶⁷

Affiliation:

1. Cancer Risk, Detection, and Interception Program, Duke Cancer Institute, Durham, North Carolina, USA;

2. Department of Population Health Sciences, Duke University, Durham, North Carolina, USA;

3. Department of Pathology, Duke University, Durham, North Carolina, USA;

4. Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina, USA;

5. School of Medicine, Duke University, Durham, North Carolina, USA;

6. Department of Medicine, Duke University, Durham, North Carolina, USA;

7. Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina, USA;

8. School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA;

9. Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA;

10. Division of Biostatistics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Abstract

INTRODUCTION: We designed a race-conscious study to assess the presence of Helicobacter pylori virulence factor cagA in a retrospective cohort of patients with active H. pylori infection. METHODS: We compared cagA status by race in gastric tissue samples from 473 patients diagnosed with active H. pylori infection from 2015 to 2019. RESULTS: H. pylori + Black patients were 2 times more likely to be cagA + than H. pylori + White patients (82% vs 36%, P < .0001). DISCUSSION: Presence of cagA is common among endoscopy patients with active H. pylori infection; appropriate testing and treatment of H. pylori can both reduce gastric cancer risk and address health disparities.

Funder

NIH

Publisher

Ovid Technologies (Wolters Kluwer Health)

Reference17 articles.

1. Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis;de Martel;Lancet Glob Health,2020

2. Cancer statistics for African American/Black people 2022;Giaquinto;CA Cancer J Clin,2022

3. Race and ethnicity-conscious clinical research best practices;Barrett-Campbell;JAMA Oncol,2022

4. Differences in antibody levels to H. pylori virulence factors VacA and CagA among African Americans and Whites in the Southeast USA;Butt;Cancer Causes Control,2020

5. Racial differences in Helicobacter pylori CagA sero-prevalence in a consortium of adult cohorts in the United States;Varga;Cancer Epidemiol Biomarkers Prev,2020