Postinfantile Giant Cell Hepatitis Secondary to Rheumatoid Arthritis

Author:

Martinez-Moad Miranda1ORCID,Wunderlich Grant1,Diep Darlene1,Vasudevan Akshay2,Russell Alison1,Janitz Tyler1,Aluri Bineetha1,Oviedo Angelica1,Mysore Rangaraju Ayyappa3

Affiliation:

1. Burrell College of Osteopathic Medicine, Las Cruces, NM

2. Boston University, Boston, MA

3. Memorial Medical Center, Las Cruces, NM

Abstract

ABSTRACT Postinfantile giant cell hepatitis (PIGCH), also known as syncytial giant cell hepatitis, continues to be a poorly defined and rare disease presentation in the adult population. Although a common finding in neonates, there is limited literature on the disease process, causes, and treatment success of PIGCH in adults. A strong association between autoimmune disorders and PIGCH, considerably so in the case of autoimmune hepatitis, has been established. However, there have been limited to no reports of PIGCH secondary to rheumatoid arthritis. Our clinical case aims to bring forth a vignette of PIGCH to spotlight this ill-defined disease in the adult population and highlight some of the proposed causes, treatments, and laboratory markers.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Reference12 articles.

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4. Postinfantile giant-cell transformation in hepatitis;Devaney;Hepatology.,1992

5. Syncytial giant-cell hepatitis—a specific disease entity?;Lau;J Hepatol.,1992

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