Posterior Reversible Encephalopathy Syndrome After Infliximab Infusion for Fistulizing Crohn's Disease

Author:

Abdoh Qusay1,Rabi Razan2ORCID,Musmar Basel3,Abuhassan Ahmad4,Barqawi Abdulkareem5

Affiliation:

1. Department of Gastroenterology, An-Najah National University Hospital, Nablus, Palestine

2. Department of Internal Medicine, An-Najah National University Hospital, Nablus, Palestine

3. Department of Medicine, An-Najah National University, Nablus, Palestine

4. Department of Neurology, An-Najah National University Hospital, Nablus, Palestine

5. Department of Surgery, An-Najah National University Hospital, Nablus, Palestine

Abstract

ABSTRACT Biologic therapy is the mainstay of treatment of complicated inflammatory bowel diseases, which has numerous potential side effects. Among these is a rare condition known as posterior reversible encephalopathy syndrome (PRES), which is a reversible neurological disorder that results in symptoms such as headache, nausea/vomiting, blurry vision, and seizure and is diagnosed based on specific clinical and radiological features. This report presents a case of a 19-year-old woman with fistulizing Crohn's disease who was treated with infliximab, but subsequently developed PRES, which was manifested as recurrent episodes of seizures and elevated blood pressure readings, was managed supportively with antiepileptic and antihypertensive medications and eventually made a full recovery, even after resuming infliximab. This case adds to the fewer than 10 previously reported cases of PRES associated with biological therapy for inflammatory bowel disease. It highlights the need to consider this complication when prescribing these drugs.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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1. Benzodiazepines/infliximab/phenytoin;Reactions Weekly;2024-07-20

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