Subcutaneous Sweet Syndrome Successfully Treated With Ustekinumab in a Patient With Ulcerative Colitis

Author:

Hu Kelly A.1,Shen Jeanne2,Rieger Kerri3,Wei Mike T.14,Gubatan John14ORCID

Affiliation:

1. Department of Medicine, Stanford University School of Medicine, Stanford, CA

2. Department of Pathology, Stanford University School of Medicine, Stanford, CA

3. Department of Dermatology, Stanford University School of Medicine, Stanford, CA

4. Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA

Abstract

ABSTRACT Ustekinumab, an inhibitor of the interleukin-12/23 pathway, received Food and Drug Administration (FDA) approval in 2019 for induction and maintenance therapy in patients with moderate-to-severe ulcerative colitis (UC). Data regarding the efficacy of ustekinumab in the treatment of extraintestinal manifestations of UC are unclear. Sweet syndrome, an acute febrile neutrophilic dermatosis, is a cutaneous manifestation of inflammatory bowel disease that parallels disease activity. In this study, we present the first case of subcutaneous Sweet syndrome with sterile osteomyelitis in a patient with UC successfully treated with ustekinumab.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Treatment Strategies in Neutrophilic Dermatoses: A Comprehensive Review;International Journal of Molecular Sciences;2023-10-26

2. A critical review of ustekinumab for the treatment of active ulcerative colitis in adults;Expert Review of Gastroenterology & Hepatology;2023-03-26

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