Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency-Reference-Cited by-同舟云学术

Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency

Published:2023-09 Issue:9 Volume:10 Page:e01143
ISSN:2326-3253
Container-title:ACG Case Reports Journal
language:en
Short-container-title:ACG Case Rep J

Author:

Elkin Baila¹^ORCID,Allende Daniela S.²,Sengupta Shreya³

Affiliation:

1. Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH

2. Pathology Department, Cleveland Clinic Foundation, OH

3. Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH

Abstract

ABSTRACT Liver transplant is a rare phenomenon for pyruvate kinase deficiency (PKD)-related liver disease and can be mediated by multiple mechanisms. In this report, we present a 55-year-old man with PKD who had acute-on-chronic liver failure with kidney failure and marked hyperbilirubinemia. His liver disease was from recurrent cholangitis, cholestasis from hemolysis, and iron deposition (likely from both repeated transfusions in youth and chronic hemolysis), all consequences of his PKD. He received a liver transplant and had a good outcome. Our case highlights the mechanisms of liver injury in PKD and successful transplantation for this rare complication.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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