Icteric Variant of Stauffer Syndrome as a Paraneoplastic Manifestation of Type 1 Papillary Renal Cell Carcinoma

Author:

Sorda Juan Antonio1,Barreyro Fernando Javier2ORCID,Rojas German1,Greco Daniel Alejandro3,Paes Andrea3,Avagnina Alejandra3,Daruich Jorge1,Ballerga Esteban González1

Affiliation:

1. Department of Gastroenterology and Hepatology, University Hospital “José de San Martín”, Faculty of Medicine, University of Buenos Aires, Argentina

2. Laboratory of Molecular Biotechnology (BIOTECMOL), Biotechnology Institute of Misiones (INBIOMIS), National University of Misiones, National Scientific and Technical Research Council (CONICET), Argentina

3. Department of Pathology, University Hospital “José de San Martín,” Faculty of Medicine, University of Buenos Aires, Argentina

Abstract

ABSTRACT Intrahepatic cholestasis as a paraneoplastic manifestation was first described by Dr. Maurice H. Stauffer in 1961. This paraneoplastic manifestation was primarily associated with renal cell carcinoma characterized by abnormal liver enzymes without hepatic metastasis. Stauffer syndrome is classified into 2 types: classical and jaundice variants. Indeed, the jaundice variant is extremely rare and only described in 13 published cases. We report a case of intrahepatic cholestasis associated with a type 1 papillary renal cell carcinoma with complete resolution after surgical treatment.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

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