Higher Serrated Polyp Detection Rates Are Associated With Lower Risk of Postcolonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry

Author:

Anderson Joseph C.1234ORCID,Rex Douglas K.5,Mackenzie Todd A.1,Hisey William36,Robinson Christina M.36,Butterly Lynn F.136

Affiliation:

1. Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA;

2. White River Junction VAMC, White River Junction, Vermont, USA;

3. New Hampshire Colonoscopy Registry, Lebanon, New Hampshire, USA;

4. University of Connecticut, Storrs, Connecticut, USA;

5. Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA;

6. Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Abstract

INTRODUCTION: We used New Hampshire Colonoscopy Registry data to examine the association between postcolonoscopy colorectal cancer (PCCRC) and sessile serrated detection rates (SSLDRs). METHODS: We included patients with either a colonoscopy or a CRC diagnosis in the NH State Cancer Registry. PCCRC was any CRC diagnosed ≥ 6 months after index examination. RESULTS: Of 26,901 patients, 162 were diagnosed with PCCRC. The hazard ratio for PCCRC was lowest for patients whose endoscopists had the highest SSLDR quintile (≥6%) (hazard ratio 0.29; 95% confidence interval 0.16–0.50). DISCUSSION: Endoscopists with higher SSLDRs had lower risks of PCCRC. These data validate SSLDR as a clinically relevant quality measure.

Funder

Division of Cancer Prevention, National Cancer Institute

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology

Reference19 articles.

1. Techniques for detection and complete resection of sessile serrated polyps;Anderson;Gastroenterol Hepatol (N Y),2021

2. Colorectal cancer screening for the serrated pathway;Anderson;Gastrointest Endosc Clin N Am,2020

3. The frontiers of serrated polyps;Bell;Am J Surg Pathol,2022

4. Adenoma detection rate and risk of colorectal cancer and death;Corley;N Engl J Med,2014

5. Implementation of optical diagnosis with a “resect and discard” strategy in clinical practice: DISCARD3 study;Ahmad;Gastrointest Endosc,2022

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