Prevalence and Natural History of Segmental Colitis Associated With Diverticulosis

Author:

Tursi Antonio12ORCID,Piovani Daniele34,Brandimarte Giovanni5,Di Mario Francesco6,Elisei Walter7,Picchio Marcello8,Allegretta Leonardo9,Annunziata Maria Laura10,Bafutto Mauro11,Bassotti Gabrio12,Bianco Maria Antonia13,Colucci Raffaele14,Conigliaro Rita15,Dumitrascu Dan L.16,Escalante Ricardo17,Ferrini Luciano18,Forti Giacomo19,Franceschi Marilisa20,Graziani Maria Giovanna21,Lammert Frank2223,Latella Giovanni24,Maconi Giovanni25,Compare Debora26,Nardone Gerardo27,Camara De Castro Oliveira Lucia28,Chaves Oliveira Enio29,Papagrigoriadis Savvas30,Pietrzak Anna31,Pontone Stefano32,Stundiene Ieva33,Pranzo Giuseppe22,Reichert Matthias Christian34,Rodinò Stefano31,Regula Jaroslaw32,Scaccianoce Giuseppe35,Scaldaferri Franco36,Vassallo Roberto37,Zampaletta Costantino38,Zullo Angelo39,Spaziani Erasmo3940,Bonovas Stefanos34,Papa Alfredo36,Danese Silvio41,

Affiliation:

1. Territorial Gastroenterology Service, ASL BAT, Andria, Barletta-Andria-Trani, Italy;

2. Department of Medical and Surgical Sciences, School of Medicine, Catholic University, Rome, Italy;

3. Department of Biomedical Sciences, Humanitas University, Milan, Italy;

4. IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy;

5. Division of Internal Medicine and Gastroenterology, “Cristo Re” Hospital, Rome, Italy;

6. Department of Medical and Surgical Sciences, Gastroenterology Unit, University of Parma, Parma, Italy;

7. Division of Gastroenterology, “S. Camillo” Hospital, Rome, Italy;

8. Division of Surgery, “P. Colombo” Hospital, ASL RM6, Velletri, Rome, Italy;

9. Division of Gastroenterology, “Santa Caterina Novella” Hospital, Galatina, Lecce, Italy;

10. Division of Gastroenterology, “San Donato” Hospital, San Donato Milanese, Michigan, Italy;

11. Institute of Gastroenterology and Digestive Endoscopy, Goiânia, Goiás, Brazil;

12. Department of Medicine and Surgery, Gastroenterology and Hepatology Unit, “Santa Maria Della Misericordia” University Hospital, University of Perugia, Perugia, Italy;

13. Division of Gastroenterology, “T. Maresca” Hospital, Torre Del Greco, Naples, Italy;

14. Digestive Endoscopy Unit, “San Matteo Degli Infermi” Hospital, Spoleto, Perugia, Italy;

15. Digestive Endoscopy Unit, “Sant’Agostino Estense” Hospital, Baggiovara, Missouri, Italy;

16. 2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania;

17. Central University of Venezuela, Loira Medical Center, Caracas, Venezuela;

18. Service of Digestive Endoscopy, “Villa Dei Pini” Home Care, Civitanova Marche, Macerata, Italy;

19. Digestive Endoscopy Unit, “Santa Maria Goretti” Hospital, Latina, Italy;

20. Digestive Endoscopy Unit, ULSS7 Alto Vicentino, Santorso, Virgin Islands, Italy;

21. Division of Gastroenterology and Digestive Endoscopy “S. Giovanni-Addolorata” Hospital, Rome, Italy;

22. Department of Medicine II, Saarland University Medical Center, Homburg, Germany;

23. Health Sciences, Hannover Medical School (MHH), Hannover, Germany;

24. Division of Gastroenterology, Hepatology and Nutrition, San Salvatore Hospital, Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila, Italy;

25. Division of Gastroenterology, “L. Sacco” University Hospital, Milan, Italy;

26. Department of Clinical Medicine and Surgery, Division of Gastroenterology and Hepatology, Federico II” University Hospital, Naples, Italy;

27. Department of Anorectal Physiology, “São José” Home Care, Rio de Janeiro, Brazil;

28. Department of Colorectal Surgery, Federal University of Goiás, Goiânia, Goiás, Brazil;

29. Department of Colorectal Surgery, King's College Hospital, London, United Kingdom;

30. Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education and Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland;

31. 1st Division of General Surgery, “Umberto I” University Hospital, “Sapienza” University, Rome, Italy;

32. Institute of Clinical Medicine, Vilnius University Hospital, Vilnius, Lithuania;

33. Digestive Endoscopy Unit, “Valle D'Itria” Hospital, Martina Franca, Taranto, Italy;

34. Division of Gastroenterology, “Pugliese-Ciaccio” Hospital, Catanzaro, Italy;

35. Digestive Endoscopy Unit, “F. Perinei,” Altamura, Bari, Italy;

36. Division of Internal Medicine and Gastroenterology, IRCCS “A. Gemelli” Hospital, Fondazione Policlinico Gemelli, Catholic University, Rome, Italy;

37. Division of Gastroenterology and Digestive Endoscopy, “Bucchieri-La Ferla” Hospital, Palermo, Italy;

38. Division of Gastroenterology, “Belcolle” Hospital, Viterbo, Italy;

39. Division of Gastroenterology, “Nuovo Regina Margherita” Territorial Hospital, Rome, Italy;

40. Department of Surgery, “Sapienza” University of Rome-Polo Pontino, Terracina, Latina, Italy;

41. Gastroenterology and Endoscopy, IRCCS Ospedale “San Raffaele” and University “Vita-Salute San Raffaele,” Milan, Italy.

Abstract

INTRODUCTION: We assessed the prevalence and clinical outcomes of segmental colitis associated with diverticulosis (SCAD) in patients with newly diagnosed diverticulosis. METHODS: A 3-year international, multicenter, prospective cohort study was conducted involving 2,215 patients. RESULTS: SCAD diagnosis was posed in 44 patients (30 male patients; median age: 64.5 years; prevalence of 1.99%, 95% confidence interval, 1.45%–2.66%). Patients with SCAD types D and B showed worse symptoms, higher fecal calprotectin values, needed more steroids, and reached less likely complete remission. DISCUSSION: Although SCAD generally had a benign outcome, types B and D were associated with more severe symptoms and worse clinical course.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology

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