Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease

Author:

Valitutti Francesco12ORCID,Leonard Maureen M.34,Kenyon Victoria34,Montuori Monica5,Piemontese Pasqua6,Francavilla Ruggiero7,Malamisura Basilio8,Norsa Lorenzo9,Calvi Angela10,Lionetti Maria Elena11,Baldassarre Mariella12,Trovato Chiara Maria13,Perrone Michela6,Passaro Tiziana8,Sansotta Naire9,Crocco Marco10,Morelli Annalisa14,Raguseo Lidia Celeste7,Malerba Federica10,Elli Luca15,Cristofori Fernanda7,Catassi Carlo11,Fasano Alessio234ORCID,

Affiliation:

1. Pediatric Unit, “San Giovanni di Dio e Ruggi d'Aragona” University Hospital, Salerno, Italy;

2. European Biomedical Research Institute of Salerno, Salerno, Italy;

3. Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts, USA;

4. Celiac Research Program, Harvard Medical School, Boston, Massachusetts, USA;

5. Pediatric Gastroenterology Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;

6. NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy;

7. Pediatric Unit “Bruno Trambusti,” Osp Pediatrico Giovanni XXIII, University of Bari, Bari, Italy;

8. Celiac Disease Referral Center, “San Giovanni di Dio e Ruggi d'Aragona” University Hospital, Pole of Cava de' Tirreni, Salerno, Italy;

9. Pediatric Hepatology Gastroenterology and Transplant Unit, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy;

10. Pediatrics, IRCCS Ospedale Giannina Gaslini, Genova, Italy;

11. Pediatrics, Univ. Politec. delle Marche, Ancona, Italy;

12. NICU, University of Bari, Bari, Italy;

13. Celiac Disease Referral Center, Bambino Gesù Hospital, Rome, Italy;

14. Pediatric Training Program, University of Salerno School of Medicine, Salerno, Italy;

15. Celiac Disease Referral Center, Ospedale Maggiore Policlinico, Milan, Italy.

Abstract

INTRODUCTION: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk. METHODS: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity). RESULTS: Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion. DISCUSSION: Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology

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