Global Prevalence of Psychological Distress and Comorbidity With Disorders of Gut-Brain Interactions-Reference-Cited by-同舟云学术

Global Prevalence of Psychological Distress and Comorbidity With Disorders of Gut-Brain Interactions

Published:2023-09-18 Issue:1 Volume:119 Page:165-175
ISSN:0002-9270
Container-title:American Journal of Gastroenterology
language:en
Short-container-title:Am J Gastroenterol

Author:

Trindade Inês A.¹²^ORCID,Hreinsson Jóhann P.¹^ORCID,Melchior Chloé¹³⁴^ORCID,Algera Joost P.¹^ORCID,Colomier Esther¹⁵,Törnblom Hans¹^ORCID,Drossman Douglas⁶,Tack Jan¹⁵^ORCID,Palsson Olafur S.⁶,Bangdiwala Shrikant I.⁷⁸,Sperber Ami D.⁹^ORCID,Simrén Magnus¹⁶

Affiliation:

1. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;

2. School of Behavioural, Social and Legal Sciences, University of Örebro, Sweden;

3. INSERM UMR 1073, Institute for Research and Innovation in Biomedicine, Normandy University, Rouen, France;

4. Rouen University Hospital, Gastroenterology Department and INSERM CIC-CRB 1404, Rouen, France;

5. Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium;

6. Center for Functional GI and Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA;

7. Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada;

8. Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada;

9. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Abstract

INTRODUCTION: This study focused on defining the global prevalence of clinically relevant levels of psychological distress and somatic symptoms and the prevalence of coexistence between these symptoms and disorders of gut-brain interaction (DGBI). We also analyzed how clinically relevant psychological distress and somatic symptoms and coexistent DGBI are associated with health-related outcomes. METHODS: We included a representative sample of 54,127 adult participants (49.1% women; mean age of 44.3 years) from 26 countries worldwide. Participants completed an Internet survey (the Rome Foundation Global Epidemiology Study) with validated self-report questionnaires. RESULTS: Clinically relevant psychological distress and/or somatic symptom severity was reported by 37.5% of the sample. These participants had 4.45 times higher odds to have at least one DGBI than individuals without psychological distress and/or somatic symptoms. Compared with participants with psychological distress and/or somatic symptoms with vs without DGBI, participants with a DGBI reported increased healthcare and medication utilization (with OR from 1.6 to 2.8). Coexistent DGBI in participants with psychological distress and/or somatic symptoms was the variable most strongly associated with reduced mental (β = −0.77; confidence interval [−0.86 to −0.68]) and physical (β = −1.17; confidence interval [−1.24 to −1.10]) quality of life. DISCUSSION: This global study shows that psychological distress, somatic symptoms, and DGBI are very common and frequently overlap. The coexistence between psychological distress/somatic symptoms and DGBI seems to be especially detrimental to quality of life and healthcare utilization. Individuals with psychological distress/somatic symptoms and DGBI coexistence seem to be a group vulnerable to psychosocial problems that should be studied further and would likely benefit from psychological/psychiatric interventions.

Funder

Rome Foundation Research Institute

Ironwood Pharmaceuticals, Incorporated

Shire

Allergan

Takeda Pharmaceuticals U.S.A.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology

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