High incidence rate of CT-measured steatotic liver disease in men with and without HIV infection-Reference-Cited by-同舟云学术

High incidence rate of CT-measured steatotic liver disease in men with and without HIV infection

Published:2023-12-22 Issue: Volume: Page:
ISSN:0002-9270
Container-title:American Journal of Gastroenterology
language:en
Short-container-title:Am J Gastroenterol

Author:

Price Jennifer C.¹,Springer Gayle²^ORCID,Seaberg Eric C.²^ORCID,Budoff Matthew J.³^ORCID,Koletar Susan L.⁴^ORCID,Hawkins Claudia A.⁵^ORCID,Witt Mallory D.⁶^ORCID,Post Wendy S.²⁷,Thio Chloe L.⁸^ORCID

Affiliation:

1. Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California

2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

3. Division of Cardiology, Department of Medicine, Lundquist Institute, Torrance, California

4. Division of Infectious Diseases, Department of Medicine, The Ohio State University, Columbus, Ohio

5. Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

6. Division of HIV Medicine, Department of Medicine, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California

7. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

8. Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

Introduction: We determined steatotic liver disease (SLD) incidence in a prospective cohort of men with HIV (MWH) and men without HIV (MWOH). Methods: Incident SLD was defined using paired non-contrast CT scans performed 2010-2013 and repeated 2015-2017. Results: Of 268 men, 173 MWH and 95 MWOH, 33 had incident SLD (11.1%, incidence rate (IR) 2.4 and 2.7/100 person-years for MWH and MWOH, respectively). Overall, higher abdominal visceral adipose tissue (VAT) was independently associated with increased SLD risk. In MWH, increased VAT, insulin resistance, chronic hepatitis B, and cumulative etravirine use were associated with SLD. Discussion: Metabolic factors, but not HIV, were associated with incident SLD. The high IR suggests that SLD will continue to increase in PWH.

Funder

NIH

NHLBI

Johns Hopkins University CFAR

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology