Bone metabolism in diabetes mellitus: focus on vitamin K2

Abstract

Diabetes mellitus (DM) type 2 is reported to be among the most common diseases both worldwide and in Russian Federation, whereby chronic implications that develop under hyperglycemia pose a serious socioeconomic problem. Besides of classic microvascular complications like diabetic retinopathy, nephropathy and polyneuropathy it’s recently worthy of note the presence of high fracture risk in DM type 2 even in normal bone mass density, known as “diaporosis” or “diabetoporosis” considered as another DM complication. It is well known that osteoporosis is reported to be widespread disease as same as DM type 2 and likewise is a widely abundant in older age that makes their combination is really possible in a single patient. Taking into account high social value and disability due to osteoporotic fractures and chronic DM type 2 complications it becomes necessary to continue physiologic and biochemical basis investigations of bone formation and remodeling and pathogenesis of osteoporosis development in the context of chronic hyperglycemia. One of the fairly new factors which the experts believe it is link between impaired glucose metabolism and bone remodeling is osteocalcin which concentration is dependent on vitamin K2 maintenance considered as a potential agent in osteoporotic fractures prevention. In this review current information on vitamin K2 influence on bone status and possibility of using this nutrient in clinical practice in the focus on patients with DM will be covered.