TREATMENT OF PATIENTS wITH OSTEOPOROSIS IN MODERN CLINICAL PRACTICE: ADHERENCE TO THERAPY

Abstract

Aim. To assess the patients compliance to treatment of osteoporosis (OP). Materials and methods. Poll study of random sample of 1565 patients (86% women and 14% men) with OP aged 50 years and older (mean age 64 ± 7 years) from 10 cities of five federal districts of the Russian Federation with the duration of the disease a year or more. Results. Over the previous year before the survey, preparations for the treatment of OP took 96% of patients but were adherent to it only 40% of patients. Age, education, and the presence of any previous fractures had no effect on adherence, while the duration of the disease and the total duration of therapy contributed to its reduction (p <0.05). All patients who received zoledronic acid and denosumab had a 100% compliance. Among taking oral bisphosphonates (BP) and strontium ranelate (SR) adherence was higher compared to those who used only calcium supplements and vitamin D (p <0.005), there were no differences in treatment adherence to BF and SR, and compliance of women was not dependent on the dosing regimen of oral BF (p> 0.05). Less committed to oral drugs were women who took more other medications. The high cost, lack of necessary medicines in the pharmacy, the duration of therapy were the most common causes of omission or substitution treatment of OP. Conclusion. In our country, patients with OP have poor adherence to medical treatment. Reduced compliance to OP therapy is due to prolonged duration of the disease, total duration of the treatment, cost of drugs or their absence in the pharmacy, and in women was dependent on the number of drugs taken.