ROL' KAL'TsIY-ChUVSTVITEL'NOGO RETsEPTORA V PODDERZhANII SISTEMY KAL'TsIEVOGO GOMEOSTAZA

Abstract

Calcium-sensing receptor (CaSR), a member of G proteincoupled receptors family, plays a key role in systemic calcium homeostasis regulation. It is expressed in a variety of tissues, and is responsible for maintaining plasma calcium concentration. In addition, the CaSR is known to regulate some important cellular processes such as apoptosis and proliferation. CaSR is a drug target for calcimimetics and calcilytics, agents used for modification of parathyroid cells function and treatment of some pathologic conditions. Inactivating or activating mutations of the CaSR gene cause different disorders of calcium metabolism. Polymorphic variants of the gene have been described in healthy populations.