Author:
Lipatenkova Anna Konstantinovna,Dzeranova Larisa Konstantinovna,Pigarova Ekaterina Aleksandrovna,Astaf'eva Ludmila Igorevna,Grigor'ev Andrey Yur'evich,Shishkina Ludmila Valentinovna,Cherebilo Vladislav Yur'evich,Ektova Anastasiya Pavlovna
Abstract
Silent, or clinically nonfunctioning adenomas are morphologically heterogeneous group, characterized by positive immunoreactivity for one or more hormones classically secreted by normal pituitary cells but without clinical expression. Although in some occasions enhanced or changed secretory activity can develop over time. According to immunoreactivity they are divided into "silent" gonado-, cortico-, somato -, mammo – and thyrotropinomas, oncocytomas, «zero-cell» tumors. All types of "silent" adenomas have different biological activity, secretory capacity and outcomes in the postoperative period. This series of clinical cases shows more «aggressiveness», a higher risk of relapse for "silent" cortico- and somatotropinomas. Immunohistochemical analysis of residual tissue can be used to identify patients with high risk of recurrence, to develop optimal treatment and follow-up.
Publisher
Endocrinology Research Centre
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献