Affiliation:
1. Federal Research Center of Fundamental and Translational Medicine
Abstract
The article presents data of the influence of cytokines of different directions of glucose and lipid metabolism in obesity. A change of the basic paradigm regarding adipose tissue has contributed to a number of recent discoveries. This concerns such basic concepts as healthy and diseased adipocytes, and, as a consequence, changes of their metabolism under the influence of cytokins. Distinguishing the concept of organokines demonstrates that despite the common features of cytokine regulation, each organ has its own specifics features of cytokine regulation, each organ has its own specific an important section of this concept is the idea of the heterogeneity of adipose tissue. Knowledge of the function of adipose tissue localized in different compartments of the body is expanding. There are date about the possibility of transition of one type of adipose tissue to another. A possible mechanism linking adipose tissue inflammation and the formation of insulin resistance (IR) is presented in this paper. The mechanism of IR development is closely connected with to proinflammatory cytokins disordering the insulin signal, accompanied by a decrease of the work of glucose transporters. A decrease of the income of glucose into cells leads to a change of glycolysis level to an increase of the fatty acids oxidation. Cytokins are able to participate in the process of the collaboration of some cells with others, that occurs both during physiological and pathological process.
Publisher
Endocrinology Research Centre
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference62 articles.
1. Cheng L, Wang J, Dai H, et al. Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus. Adipocyte. 2021;10(1):48-65. doi: https://doi.org/10.1080/21623945.2020.1870060
2. Connon SRD, Soyunov MA. Infertility in the era of obesity: epidemiology and methods of its determination. Obstetrics and Gynecology: News, Opinions, Training. 2018:6(3):105-112. (In Russ.). doi: https://doi.org/10.24411/2303-9698-2018-13012
3. Bokova TA. Risk factors for the formationo of metabolic syndromein children with obesity. Russian Bulletin of Perinatology and Pediatrics. 2018:63(3):64-69 (in Russ.). doi: https://doi.org/10.21508/1027-4065-2018-63-3-64-69
4. Cheong LY, XuA. Intercellular and inter-organ crosstalk in browning of white adipose tissue : molecular mechanism and therapeutic complications. J Mol Cell Biol. 2021;13(7):466-479. doi: https://doi.org/10.1093/jmcb/mjab038
5. Somm E, Henrichot E, Pernin A, et al. Decreased fat mass in interleukin-1 receptor antagonist–deficient mice. Diabetes. 2005;54(12):3503-3509. doi: https://doi.org/10.2337/diabetes.54.12.3503
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