Association of thyroidstimulating hormone, prolactin and leptin with metabolic status in young women 25-44 years old in Western Siberia

Abstract

AIM: To study anthropometric, biochemical and hormonal characteristics of women aged 25-44 with different levels of thyroid- stimulating hormone, prolactin and leptin.MATERIALS AND METHODS: From a representative sample of the young population of the Oktyabrsky district of Novosibirsk aged 25-44 years (840 women), a group of women (n=655) was selected to study cardiometabolic and hormonal parameters. The design of the study was a cross-sectional, observational, single-centre study. All participants underwent determination of anthropometric parameters (weight, measurement of waist circumference (WC) and hips (HC), calculation of BMI), systolic and diastolic blood pressure (SBP, DBP), biochemical parameters (total cholesterol (TC), high-density lipoprotein cholesterol ( HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), fasting plasma glucose (FPG), creatinine, calculation of glomerular filtration rate (GFR).Statistical processing was carried out using the SPSS-13 package.RESULTS: The study included 655 women, mean age 36.3±5.4 years, mean BMI 25.0±5.7 kg/m2. Young women showed direct associations of TSH with HC (r=0.115, p<0.05), TG (r=0.145, p<0.010) and inverse association with GFR (r=-0.129, p<0.05). PRL is inversely associated with HC (r=-0.109, p<0.05). Of all the studied hormones, leptin is most associated with anthropometric and biochemical parameters in young women. Thus, leptin is directly associated with WC (r=0.562, p<0.0001), HC (r=0.589, p<0.0001), WC/HC index (r=0.309, p<0.0001), BMI ( r=0.582, p<0.0001), as well as levels of SBP (r=0.293, p<0.0001), DBP (r=0.274, p<0.0001), TC (r=0.123, p=0.018), TG (r=0.234, p<0.0001), FPG (r=0.150, p=0.004), inversely related to HDL-C (r=-0.225, p<0.0001).CONCLUSION: The metabolic status of women aged 25-44 is associated with the level of TSH, leptin. It is advisable to determine TSH, leptin in young women with abdominal obesity for the purpose of dynamic monitoring and correction.