Affiliation:
1. Moscow State University of Medicine and Dentistry
2. National Medical Research Center for Endocrinology
3. Moscow City Clinical Hospital 52
Abstract
Amiodarone is an antiarrhythmic drug that is widely used in clinical practice to control various types of arrhythmias. One of the most significant side effects of amiodarone therapy is thyroid dysfunction, which is observed in about 15–20% of patients. This article presents a clinical case of a 55-year-old patient with a paroxysmal form of atrial fibrillation, for which amiodarone therapy was performed with the development of manifest amiodarone-induced thyrotoxicosis, refractory to drug therapy with glucocorticosteroids and thyrostatics. Due to the ineffectiveness of drug therapy, a total thyroidectomy was performed, which led to a rapid resolution of thyrotoxicosis and normalization of the heart rhythm.
Publisher
Endocrinology Research Centre
Reference25 articles.
1. Zimetbaum P. Antiarrhythmic drug therapy for atrial fibrillation. Circulation. 2012;125(2):381-389. doi: https://doi.org/10.1161/CIRCULATIONAHA.111.019927
2. Kryukov EV, Potekhin NP, Fursov AN, et al. Algorithm of management of patients treated with amiodarone depending on thyroid functional state. Clin Med. 2017;95(10):901-905. (In Russ.). doi: https://doi.org/10.18821/0023-2149-2017-95-10-901-905
3. Martino E, Bartalena L, Bogazzi F, Braverman LE. The effects of amiodarone on the thyroid. Endocr Rev. 2001;22(2):240-254. doi: https://doi.org/10.1210/edrv.22.2.0427
4. Censi S, Bodanza V, Manso J, et al. Amiodarone-induced thyrotoxicosis: Differential diagnosis using 99mTc-SestaMIBI and Target-to-Background Ratio (TBR). Clin Nucl Med. 2018;43(9):655-662. doi: https://doi.org/10.1097/RLU.0000000000002207
5. Sviridenko NJu, Platonova NM, Molashenko NV, et al. Endocrine aspects of amiodarone therapy in clinical practice (follow-up and treatment algorithm for patients with thyroid dysfunction). Russian Journal of Cardiology. 2012;(2):63-71. (In Russ.).