Autoimmune polyglandular syndrome of adults: current ideas about predictors development of damage of a myocardium and diagnostics of components of a disease

Abstract

The autoimmune polyglandular syndrome of adults (APS) is characterized by the damage of two and more endocrine glands leading more often to development of their hormonal insufficiency. The basis of most autoimmune endocrine diseases is lymphoid and macrophage infiltration of the target organ. Often in patients with one autoimmune disease, other components of the APS appear after a some time of latent period. Besides defeat organs of endocrine system which are including to the APS also not endocrine organs can be part of autoimmune defeat. Although defeat of cardiovascular system is not included in the structure of the APS, in some clinical cases development of damage of a myocardium in the absence of clinically shown damage of heart against the background of the combined autoimmune endocrine pathology is described. The saved-up clinical this development of damage of a myocardium on the background of autoimmune endocrine insufficiency and also laboratory and instrumental methods of diagnostics is presented in the review at this state. The most promising diagnostic methods for this condition are the determination of autoantibodies to myocardial components and magnetic resonance imaging of the heart. In clinical practice, it is possible to widely use the definition of antibodies to myocardium by indirect immunofluorescence, as well as using standardized immunoenzyme test systems.The saved-up clinical this development of damage of a myocardium on the background of autoimmune endocrine insufficiency and also laboratory and instrumental methods of diagnostics is presented in the review at this state.