Author:
Vorontsova M V,Pankratova M S
Abstract
Idiopathic short stature is the commonest form of growth retardation making up a heterogeneous group of pathological conditions characterized by a highly variable clinical picture. The molecular genetic investigations into the nature of idiopathic short stature encompass a combination of the accompanying clinical symptoms and laboratory findings. The present review is concerned with the principles of diagnostic studies pertaining to idiopathic short stature and the most widespread molecular gene defects in the growth hormone-insulin-like growth factor-1 system.
Publisher
Endocrinology Research Centre
Subject
Endocrinology, Diabetes and Metabolism