Epidemiology of primary hyperparathyroidism in Russia (the first results from the database of Federal state institution «Endocrinological Research Centre»)

Abstract

To elucidate specific features of epidemiology of various forms of primary hyperparathyroidism (PHPT) in this country using the information about 561 patients accumulated for 19 years in the database of Federal state institution «Endocrinological Research Centre». The incidence of PHPT in Moscow estimated from the database of Endocrinological Research Centre for 2007 was 6.8 per 1 000 000 adult population and the prevalence as per 2009 was 3.1/100 000. These values are significantly lower than those reported by foreign authors. The men to women ratio among the patients with PHPT was 1:8. The disease largely affects subjects at the age from 50 to 60 years. By the year of 2004, the frequency of the mild form of PHPT did not exceed 20% of the total (based on 2002 Consensus criteria). It increased to 37% during the past 5 years. Conservative treatment of PHPT can be recommended to 14% of the patients presenting with sporadic disease and to 32% of those with MEN syndrome. The frequency of asymptotic PHPT and its normocalcemic forms is estimated at 5% and 9% respectively. The above results are the first data on epidemiology of PHPT in this country; however, they are insufficient to comprehensively evaluate the real significance of the problem. Large-scale epidemiological studies are needed to ensure adequate assessment of the situation.