Effect of a complex of corticosteroids with apolipoprotein A-I on protein biosynthesis in cultured hepatocytes

Abstract

A complex of apolipoprotein A-I with steroid hormones containing reduced Δ4, 3-ketogroup in the A ring was shown to increase the rate of protein synthesis in the cultured rat hepatocytes. The biological activity of the hormones depends on the position of the oxygroup of the third carbonic atom and hydrogen at the fifth position of a carbonic atom. The cis-position is more preferable for the biological effect. The oxygroup at the third position of the A-ring may be replaced by the sulfo-group. The complex of dehydroepiandrosterone sulphate with apolipoprotein A-I increases the rate of protein biosynthesis in the cultured rat hepatocytes, which confirms the involvement of this hormone in the regulation of gene expression.