Evolution of insulin therapy: past, present, future

Author:

Kurkin D. V.1ORCID,Bakulin D. A.2ORCID,Robertus A. I.3ORCID,Kolosov Yu. A.1ORCID,Krysanov I. S.1ORCID,Morkovin E. I.1ORCID,Strygin A. V.2ORCID,Gorbunova J. V.1ORCID,Makarenko I. E.4ORCID,Drai R. V.4ORCID,Makarova E. V.5ORCID,Pavlova E. V.1ORCID,Kudrin R. А.2ORCID,Ivanova O. V.1ORCID

Affiliation:

1. Moscow State University of Medicine and Dentistry of A.I. Evdokimov

2. Volgograd State Medical University

3. Moscow State University of Medicine and Dentistry of A.I. Evdokimov; Pirogov Russian National Research Medical University

4. Pharm-Holding

5. Moscow State University of Medicine and Dentistry of A.I. Evdokimov; Universidad de Santiago de Compostela

Abstract

2021 marks the 100th anniversary of the discovery of insulin, an event that forever changed the lives of people with diabetes mellitus. At present patients around the world experience the miracle of insulin therapy every day. A disease that used to kill children and teenagers in 2 years in 1920 has become a disease that can be controlled with a possibility to lead a long productive life. Over the past century, the great discovery of Banting, Best and Collip has forever changed the world and saved millions of lives. This review is devoted to the history of the development of insulin and its further improvement: from the moment of discovery to the present days. Various generations of insulin are considered: from animals to modern ultrashort and basal analogues. The article ends with a brief review of current trends in the development of new delivery methods and the development of new insulin molecules. Over the past century, insulin therapy has come a long way, which has significantly improved the quality of life of our patients. But research is actively continuing, including in the field of alternative methods of insulin delivery, which are more convenient for the patient, as well as in the development of «smart» molecules that will have a glucose-dependent effect.

Publisher

Endocrinology Research Centre

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3