Affiliation:
1. Samara State Medical University
Abstract
Metabolic syndrome is a symptom complex that is based on visceral obesity and insulin resistance. Its prevalence is quite high, which is a big problem, since this condition increases the risk of developing cardiovascular diseases and mortality from them. Metabolic syndrome includes, in addition to abdominal obesity, arterial hypertension, disorders of carbohydrate, lipid and purine metabolism. Visceral adipose tissue plays a key role in the formation of insulin resistance and other components of the metabolic syndrome. This is due to the fact that abdominal fat, in contrast to subcutaneous fat, synthesizes pro-inflammatory cytokines, as well as adipokines — adipose tissue hormones that are involved in the formation of insulin resistance, affect carbohydrate and fat metabolism and the cardiovascular system. These include leptin, adiponectin, resistin, apelin and others. Some adipokines have an adverse effect on metabolism and increase cardiovascular risks, while others, on the contrary, have a positive effect. Taking into account their role in the development of the components of the metabolic syndrome, the possibilities of a therapeutic effect on the hormones of adipose tissue to improve metabolic processes and prevent complications associated with it are discussed.
Publisher
Endocrinology Research Centre
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference76 articles.
1. Oganov RG, Simanenkov VI, Bakulin IG, et al. Comorbid pathology in clinical practice. Diagnostic and treatment algorithms. Cardiovascular Therapy and Prevention. 2019;18(1):5-66. (In Russ.). doi: https://doi.org/10.15829/1728-8800-2019-1-5-66.
2. Hanefeld M, Leonhardt W. Das metabolische Syndrom. Dtsch Gesundh Wesen. 1981;36: 545–551.
3. Recommendations for the management of patients with metabolic syndrome. Clinical guidelines Ministry of Health of the Russian Federation. 2013. 43 p. (In Russ.). Доступно по: https://mzdrav.rk.gov.ru/file/mzdrav_18042014_Klinicheskie_rekomendacii_Metabolicheskij_sindrom.pdf. Ссылка активна на 09.12.2020.
4. Badin YuV, Fomin IV, Belenkov YuN, et al. EPOCHA-AH 1998–2017. Dynamics of prevalence, awareness of arterial hypertension, treatment coverage, and effective control of blood pressure in the Еuropean part of the Russian Federation. Kardiologiya. 2019;59(1S):34-42. (In Russ.). doi: https://doi.org/10.18087/cardio.2445
5. Dedov II, Shestakova MV, Vikulova OK, et al. Atlas of diabetes register in Russian Federation, status 2018. Diabetes mellitus. 2019;22(S2-2):4-61. (In Russ.). doi: https://doi.org/10.14341/DM12208
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献