1. a Faculty of Life Sciences , University of Manchester , United Kingdom
2. b MRC Centre for Neurodegeneration Research , Kings College , London, United Kingdom
3. c Department of Biochemistry, and Department of Medical Genetics & Microbiology, Faculty of Medicine , University of Toronto , Toronto, Canada
4. d Institute for Evolution and Biodiversity, School of Biological Sciences , University of Münster , Huefferstrasse 1, Münster, D48 149, Germany E-mail: