Male breast cancer

Abstract

Male Breast Cancer (MBC) accounts for 1% of breast cancers. Male breast cancer mainly occurs due to hormonal imbalances and gene changes (mutations). Risk factors for MBC include age, genetic mutations, radiation therapy, chemotherapy, family history of breast cancer, high estrogen exposure, etc. The genetic background of male breast cancer is very different from female breast cancer. The most common genes that have been associated with MBC include BRCA1&2, PALB2, CHEK2, and ATM genes. The most common clinical features of male breast cancer are lump formation, nipple discharge, inversion of nipple, skin dimpling, and redness in the breast region. In this chapter, we have described male breast cancer (MBC) in a detailed manner and some interesting case reports and research studies reported across the globe.