Cross-talk between ubiquitin ligase and breast carcinogenesis
Author:
Doshi Ankita A1, Mishra Vivek1
Affiliation:
1. Division of Biomedical and Life Sciences, School of Science, Navrachana University, Vadodara, Gujarat, India
Abstract
Ubiquitin Proteosome System (UPS) plays a pivotal role in keeping a check on protein stability and removal of misfolded or unwanted proteins in order to maintain homeostasis of the cell. Findings to date show majorly its proteolytic function and great diversity of non-proteolytic involvement in cell signaling, cell cycle, apoptosis, cell proliferation, development, cell migration, DNA repair, genome stability, inflammation, protein trafficking, etc. This diverse array of functions is being carried out due to the presence of various ubiquitin ligase E3s that confers the substrate specificity. It is noteworthy that scientific evidence related to carcinogenesis shows the central role of UPS in tumor development as most of the proteins responsible for cancer development i.e., oncogenes or tumor suppressor genes, belong to ubiquitin ligase E3. This chapter is a comprehensive summary of E3s that show either genetic or expression aberration specific to breast cancer. Primarily such E3s are involved in the cell cycle, apoptosis, cell proliferation, and DNA repair mechanism. Understanding these pathways pave the way to identifying and developing the E3s as a diagnostic marker and drug target for breast cancer.
Publisher
The Applied Biology & Chemistry Journal
Subject
Community and Home Care,Marketing,Organizational Behavior and Human Resource Management,Strategy and Management,Drug Discovery,Pharmaceutical Science,Pharmacology,General Medicine,General Medicine,General Medicine,General Medicine,General Medicine,General Earth and Planetary Sciences,General Environmental Science,General Earth and Planetary Sciences,General Environmental Science,General Medicine
Reference123 articles.
1. Adhikary, S., Marinoni, F., Hock, A., Hulleman, E., Popov, N., et al. (2005). The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell, 123(3):409-421. https://doi.org/10.1016/j.cell.2005.08.016 2. Åkerfelt, M., Morimoto, R. I., & Sistonen, L. (2010). Heat shock factors: integrators of cell stress, development and lifespan. Nat. Rev. Mol. Cell Biol, 11:545. https://doi.org/10.1038/nrm2938 3. Andrio, E., Lotte, R., Hamaoui, D., Cherfils, J., Doye, A., et al. (2017). Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation. Sci rep, 7:44779. https://doi.org/10.1038/srep44779 4. Antoniou, A. C., Casadei, S., Heikkinen, T., Barrowdale, D., et al. (2014). Breast-cancer risk in families with mutations in PALB2. NEJM, 371(6):497-506. https://doi.org/10.1056/NEJMoa1400382 5. Ardley, H. C., & Robinson, P. A. (2004). The role of ubiquitin-protein ligases in neurodegenerative disease. J. Neurodegener. Dis, 1:71-87. https://doi.org/10.1159/000080048
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